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Some patients report mild appetite suppression or increased fullness within the first week after their initial injection, though many notice no immediate effects

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This guide explains what each of these peptides actually does, why people combine them, what the law and the evidence say in the UK, and what the licensed alternatives look like in 2026

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A reasonable approach includes: Baseline thyroid function tests (TSH and FT4) before starting GLP-1 therapy Repeat testing at 812 weeks after commencing treatment, particularly if significant weight loss occurs Further monitoring at 6 months , then annually if thyroid function remains stable Additional testing if symptoms of thyroid dysfunction develop After any levothyroxine dose change, NICE NG145 recommends re-checking thyroid function in 68 weeks to assess the adequacy of the adjustment